This procedure is similar to egg donation. However, instead of borrowing the egg and using the recipients husband's sperm for fertilization, both the egg and the sperms are derived from donors
All the patients who are eligible for egg donation can also be eligible for embryo donation. In egg donation, there are the problems of getting patients to donate their eggs. Furthermore it is a relatively costly procedure, as compared to embryo donation. Embryo donation also yields the highest pregnancy rate-as high as 30-40%. Hence if the couple has no objection in using donor sperm, it is a preferred method of choice!
In our program there are many young patients who need IVF / ICSI procedure, but who cannot afford it. These patients produce lot of eggs and hence many embryos
After taking proper informed consent of these patients, some of the extra embryos are used for the recipients. In return, the costs of the drugs of the y ounger patient are borne by the recipient. This embryo sharing is beneficial for both the patients.
Alternatively, when we perform IVF, young women often produce many eggs, and therefore, many embryos. The best quality embryos are transferred into the womb. The extra embryos can be frozen and stored in liquid nitrogen at (minus)-196 0C. If the patient gets pregnant and do not want more children, they often agree to donate their embryos to other infertile couples, to help them to start a family.
Of course there is voluntary donation by family, friends or altruistic individuals. However this is rare.
The pregnancy rate in our clinic is 30-40% per cycle. The reason for the high pregnancy rate is two fold. Firstly, these are often excellent quality embryos. Also, since we prepare the Endometrium using hormones, the uterine receptivity to these embryos is usually very good.
This is similar to egg donation. In patients who are menstruating (having their periods) the hormonal control of the cycle is taken over by starting GnRh Analogue Injection such as Suprefact, Lupride or Nasaral spray starting from 21st day of previous cycle. Once the patient gets her period, Estradiol Valerate tablets( Progynova 2 mg) is started from the 2nd day of period. On the 10th day an ultrasound is done to assess the receptivity of the Endometrium by measuring its thickness.
An Endometrial thickness of more than 9mm is good for pregnancy. Once this is achieved, one can wait to obtain good quality embryos, to place back into the womb. It is important to note that with this regime, one can wait for as many as 35 days after starting Progynova, for an embryo transfer. The procedure is non-surgical, and there is no risk involved.
In case of menopausal woman, who have stopped having periods, cyclical hormones are given for 3-6 months till the time the patient starts having her periods. After that the procedure is the same, starting with Progynova tablets from the second day of period. In these women, there is no need to give GnRh analogues such as Suprefact, as the hormonal control has been naturally shut of.
In our clinic, embryo donation is totally anonymous, unless it done by a friend or relative of the recipient. There is no contact between the donating couple and the recipients, who never see each other. There are no records maintained about the origin and the ultimate resting place of the embryos.